12/24/2022 0 Comments Websites like gygan![]() Life Sci 35:1885–1893īlackburn KJ, French PC, Merrills RJ (1967) 5-Hydroxytryptamine uptake by rat brain in vitro. Neuropharmacol 25:931–933īillard W, Ruperto V, Crosby G, Iorio LC, Barnett A (1984) Characterization of the binding of 3H-SCH 23390, a selective D 1 receptor antagonist ligand, in rat striatum. Br J Addict 65:35–37īerger P, Jacobsen AE, Rice KC, Lessor RA, Reith MA (1986) Metaphit, a receptor acylator, inactivates cocaine binding sites in striatum and antagonizes cocaine-induced locomotor stimulation in rodents. Pharmacol Biochem Behav 4:103–106īejerot N (1970) A comparison of the effects of cocaine and central stimulants. Psychopharmacology 48:165–173Īnisman H (1976b) Role of stimulus locale on strain differences in active avoidance after scopolamine or d-amphetamine treatment. Neuropharmacology 14:835–840Īnisman H (1976a) Effects of scopolamine and d-amphetamine on locomotor activity before and after shock: a diallel analysis in mice. The further use of genetic methods, however, may aid in determining the specific sites of action of these widely used stimulant drugs.Īnisman H, Gygan D (1975) Central effects of scopolamine and (+)-amphetamine on locomotor activity: Interaction with strain and stress variables. These findings support the conclusion that these two drugs produce their locomotor stimulant effects through different sites of action, and that genetic differences in response to these drugs at the behavioral level do not appear to be mediated significantly by differences in structure or number of striatal dopaminergic sites. No differences in these receptor binding parameters were found. Since striatal dopaminergic neurons influence locomotor activity, we also assessed ligand affinity and receptor density of dopamine transporters and dopaminergic D 1 and D 2 receptors in striatal tissue from these same strains of rats. Further, significant strain by drug interactions were found, in that the strain rank order for stimulant response to the two drugs was not identical. However, large potency and efficacy differences were found. ![]() Dose-dependent increases in locomotor activity were found for both drugs in all strains. ![]() This study examined the effects of cocaine or amphetamine on locomotor activity in rats from the ACI, F344, LEW and NBR inbred strains. Biochemically, evidence suggests specific involvement of dopaminergic systems, although not necessarily identical sites, in mediating cocaine- and amphetamine-induced locomotor stimulation. Cocaine and amphetamine produce several behavioral effects, most notably locomotor stimulation.
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